Relative mean differenceequal to twice the Gini coefficient Entropy:
No differences were observed in analyses that were stratified by genetic polymorphisms affecting caffeine metabolism. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain.
We used baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up beginning in and ending into estimate hazard ratios HRs for coffee intake and mortality, using multivariable-adjusted Cox proportional hazards models.
Over 10 years of follow-up, 14 deaths occurred. Coffee drinking was inversely associated with all-cause mortality.
Using non—coffee drinkers as the reference group, HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0. Similar associations were observed for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score.
For example, the HRs for 6 or more cups per day ranged from 0.
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These findings suggest the importance of noncaffeine constituents in the coffee-mortality association and provide further reassurance that coffee drinking can be a part of a healthy diet.Patent bar exam study guide.
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