Effects of tobacco use on the

Both behavioral treatments and medications can help people quit smoking, but the combination of medication with counseling is more effective than either alone. Department of Health and Human Services has established a national toll-free quitline, QUIT-NOW, to serve as an access point for anyone seeking information and help in quitting smoking.

Effects of tobacco use on the

MORBIDITY Tables through summarize the preclinical health effects and morbidity caused by cigarette smoking, organized according to whether the effects occur in the immediate, intermediate, or long-term time horizon and by the stages of life usually affected by the health outcome.

Effects of tobacco use on the

Immediate Health Effects Cigarette smoking causes a constellation of subclinical health effects that occur shortly after initiation of smoking. As described below, these immediate adverse health effects include increased oxidative stress; depletion of selected bioavailable antioxidant micronutrients; increased inflammation; impaired immune status; altered lipid profiles; poorer self-rated health status; respiratory symptoms, including coughing, phlegm, wheezing, and dyspnea; and nicotine addiction.

Physiologic markers of diminished health status include subclinical outcomes such as increased oxidative stress, reduced antioxidant defenses, increased inflammation, impaired immune status, and altered lipid profiles see Tables through Smoking's impacts on such short-term physiologic outcomes impair the smoker's overall health status, which in turn renders the smoker more susceptible to various adverse health outcomes, such as developing acute illnesses, respiratory symptoms, and a lessened capacity to heal wounds.

One downstream marker of the diminished health status induced by cigarette smoking is that smokers are more likely to miss school and work. In short, soon after the initiation of smoking, an array of smoking-induced short-term deleterious health effects sets in motion a lifelong trajectory that leaves persistent smokers highly disadvantaged compared to their counterparts who never smoked.

By looking at the immediate and intermediate adverse health effects of cigarette smoking, it is clear that cigarette smoking contributes in important ways to suboptimal health beginning shortly after smoking initiation—long before the chronic diseases that smoking causes at older ages become clinically apparent HHS, Physiologic Markers of Diminished Health Status Increased oxidative stress Cigarette smoke contains free radicals and other oxidants in abundance.

A single puff of a cigarette exposes the smoker to more than free radicals in the gas phase and additional radicals and oxidants in the tar phase Pryor and Stone, The biological impacts of the oxidative stress induced by cigarette smoking have been extensively documented in humans HHS, These include oxidative injury to proteins, DNA, and lipids.

Assaying protein carbonyls is one method of measuring oxidative damage to proteins, and protein carbonyl concentrations have been observed to be significantly higher in smokers than in nonsmokers Kapaki et al.

One way of quantifying the oxidative damage to DNA is to measure the DNA damage in peripheral white blood cells induced by the hydroxyl radical at the C8 position of guanine, 8-hydroxy-deoxyguanosine 8-OH-dG.

Most of the available evidence indicates that current smokers have concentrations of 8-OH-dG in peripheral leukocytes that are at least 20 percent higher than nonsmokers HHS, Measures of lipid peroxidation include F2-isoprostanes and malondialdehyde MDA.

Many studies have demonstrated that current smokers have substantially higher concentrations of isoprostanes in both plasma and urine than nonsmokers Bloomer et al. The results of several studies indicate that MDA concentrations are 30 percent more abundant in current-versus-nonsmokers, suggesting cigarette smoking directly increases MDA concentrations Bloomer et al.

This is further corroborated by evidence from several studies that have found concentrations of thiobarbituric acid—reactive substances TBARS found in MDA range from 6 percent to percent more in smokers than in people who have never smoked HHS, Cigarette smoking clearly generates substantial quantities of oxidative stress, as indicated by a consistent body of evidence indicating that cigarette smoking significantly increases biomarkers of oxidative damage to proteins, DNA, and lipids.

Cigarette smokers experience measurable and immediate oxidative damage. This oxidative damage, experienced over long periods of time, is one pathway contributing to smoking-caused disease and death HHS, Depletion of circulating antioxidant micronutrient concentrations Cigarette smoking exposes the smoker to potential oxidative damage not experienced by the nonsmoker.

Central nervous system

One direct result of the exposure to oxidative stress is the depletion of the body's defenses against oxidative stress. For example, the antioxidant defense system is partly comprised of antioxidant micronutrients Evans and Halliwell, Antioxidant status provides a biomarker of health status because oxidative damage is thought to be centrally involved in the aging process as well as in enhanced susceptibility to a wide range of specific diseases.

Evidence from a number of studies firmly establishes that smokers have circulating concentrations of ascorbic acid and provitamin A carotenoids such as a-carotene, b-carotene, and cryptoxanthin that are more than 25 percent lower than nonsmokers Alberg, Considered in total, a strong and diverse body of evidence consistently implicates oxidative stress from cigarette smoking in the depletion of antioxidant micronutrients in circulation.

Furthermore, the results across studies are consistent with a dose—response relationship, with the amount of smoking being inversely related to the circulating concentrations of vitamin C and provitamin A carotenoids HHS, The immediate effects of cigarette smoking on these concentrations have been examined with measurements of circulating micronutrient concentrations taken before and after a smoker stops smoking.

One such study, for example, found substantially increased concentrations of vitamin C and provitamin A carotenoids after 84 hours without a cigarette Brown, In another study, the exposure of plasma to the equivalent of six puffs of cigarette smoke completely depleted the ascorbic acid present in the serum Eiserich et al.

In yet another, measurements taken at baseline and 20 minutes after smoking a cigarette found decreased circulating micronutrient concentrations Yeung, Results such as these highlight the immediate impact that smoking a cigarette can have on health status.

Cigarette smoking causes depletion of antioxidant micronutrients, leading smokers to have lower circulating concentrations of these antioxidant micronutrients than nonsmokers.Information on diseases caused by tobacco use, such as cancer, heart disease, and respiratory diseases.

Also find information on the health effects of smoking during pregnancy.

DrugFacts: Cigarettes and Other Tobacco Products | National Institute on Drug Abuse (NIDA)

Get the full chew experience and flavor without tobacco or any artificial ashio-midori.commint · Tobacco Free · Cherry · Wintergreen. The scope of the burden of disease and death that cigarette smoking imposes on the public's health is extensive. Cigarette smoking is the major focus of this chapter because it is the central public health problem, but the topics of secondhand smoke exposure, smoking of other combustible tobacco products, smokeless tobacco, and electronic nicotine delivery systems (ENDS) are also considered.

After prolonged tobacco consumption the user can quickly develop an addiction due to the addictive substance nicotine that is in tobacco.


There are many negative health effects caused by the use of tobacco. Lung, throat, and tongue cancer can all be caused by regular use of tobacco products. Information on diseases caused by tobacco use, such as cancer, heart disease, and respiratory diseases.

Also find information on the health effects of .

Tobacco - The Negative Effects of Tobacco & Nicotine Addiction

What are other health effects of tobacco use? Although nicotine is addictive, most of the severe health effects of tobacco use comes from other chemicals. Tobacco smoking can lead to lung cancer, chronic bronchitis, and emphysema.

It increases the risk of heart disease, which can .

DrugFacts: Cigarettes and Other Tobacco Products | National Institute on Drug Abuse (NIDA)